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Cytomegalovirus antibody and vascular pathology in renal transplant recipients
Author(s) -
Price Patricia,
Lee Silvia,
Affandi Jacquita,
Parsons Richard,
Naylor Louise H.,
Watts Gerald F.,
Irish Ashley
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24602
Subject(s) - cytomegalovirus , medicine , betaherpesvirinae , transplantation , brachial artery , immunology , vascular disease , antibody , human cytomegalovirus , complication , renal transplant , cytomegalovirus infection , pathology , viral disease , herpesviridae , virus , blood pressure
Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls ( P < 0.001), and correlated with vascular endothelial function measured by flow mediated‐dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect ( P = 0.068), with age ( P = 0.013), gender ( P < 0.0001), and transplantation ( P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177–181, 2017 . © 2016 Wiley Periodicals, Inc.