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HHV‐6 and seizure: A systematic review and meta‐analysis
Author(s) -
Mohammadpour Touserkani Fatemeh,
GaínzaLein Marina,
Jafarpour Saba,
Brinegar Katelyn,
Kapur Kush,
Loddenkemper Tobias
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24594
Subject(s) - meta analysis , virology , medicine , psychology
Human herpesvirus‐6 (HHV‐6) is a common infection in childhood. This systematic review aims to assess the relationship between HHV‐6 infection and seizure disorders based on available literature. MEDLINE database was searched using a search strategy. We included studies that were published after 1993 in English, and described patients with HHV‐6 infection and accompanying seizure or status epilepticus. We identified 503 articles, and included 147 studies. Meta‐analysis results showed a 0.21 detection rate of HHV‐6 in febrile seizure patients. In the febrile seizure group (110 cases), 76 patients had simple and 34 had complex febrile seizures. Patients with “HHV‐6 infection and status epilepticus” had a mean age of 16.24 months. In children with febrile illnesses, a higher index of clinical suspicion for HHV‐6 infection may be required. Further studies including CSF and brain tissue may be needed to validate relationships between HHV6 infection and epilepsy. J. Med. Virol. 89:161–169, 2017 . © 2016 Wiley Periodicals, Inc.