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Adenovirus infection among allogeneic stem cell transplant recipients
Author(s) -
César Pereira Santos Hugo,
Nunes Vieira Almeida Tâmera,
Souza Fiaccadori Fabíola,
das Dôres de Paula Cardoso Divina,
de Moraes Arantes Adriano,
Delleon da Silva Hugo,
Resende Alo Nagib Patricia,
Souza Menira
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24579
Subject(s) - viral load , feces , diarrhea , hematopoietic stem cell transplantation , virology , viral disease , immunology , medicine , transplantation , virus , graft versus host disease , biology , microbiology and biotechnology
The human adenovirus (HAdV) infection can cause severe disease in immunocompromised patients, such as those undergoing allogeneic hematopoietic stem cell transplant (ASCT). The main objective of this study was to prospectively monitor ASCT recipients for HAdV occurrence in a reference center in Brazil, and also to correlate viral positivity, viral load, molecular variant, clinical symptoms, and patients’ prognosis. From October/2012 to October/2014, blood and feces of 21 ASCT recipients were screened for HAdV by Nested‐PCR. Viral loads were determined by real‐time PCR. In total, 57% of the patients had at least one positive sample (serum or feces) for HAdV. Patients presented significantly higher viral load in feces when compared to serum. Positive samples were characterized as HAdVs of species HAdV‐C, ‐D, and ‐F. The main clinical symptom presented by infected patients was diarrhea, and Graft‐versus‐host disease (GVHD) was the main intercurrence. An association was observed between HAdV‐positivity and diarrhea and also between HAdV‐positivity and GVHD. Results from this study may contribute to a better understanding of the HAdV infection pattern in patients submitted to ASCT. Data therein highlight the importance of including HAdV testing during all routine laboratory exams performed on ASCT patients. J. Med. Virol. 89:298–303, 2017 . © 2016 Wiley Periodicals, Inc.