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Genetic diversity of hepatitis B virus (HBV) in Madagascar
Author(s) -
Andriamandimby Soa Fy,
Lo Presti Alessandra,
Lai Alessia,
Olive MarieMarie,
Angeletti Silvia,
De Florio Lucia,
Cella Eleonora,
Razafindramparany Minoharimbola,
Ravalohery JeanPiere,
Andriamamonjy Seta,
Gioffrè Sonia,
Zehender Gianguglielmo,
Mottini Giovanni,
Ciccozzi Massimo,
Heraud JeanMichel
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24576
Subject(s) - virology , hepatitis b virus , phylogenetic tree , genotype , genetic diversity , population , gene flow , biology , orthohepadnavirus , virus , molecular epidemiology , hepadnaviridae , genetic variation , gene , genetics , medicine , environmental health
Hepatitis B virus (HBV) is a DNA virus belonging to Hepadnaviridae family. Chronic infection with HBV is one major risk factor of hepatic disease. In Madagascar, former studies classified the country as part of high endemic area, as HBV prevalence can reach 23% in general population. However, this prevalence differs largely between urban and rural areas and is estimated to be, respectively, 5% and 26%. The aims of the present study were to describe the genetic diversity of HBV strains from different regions of Madagascar, and to describe the viral gene flow throughout the country by using phylogenetic analysis. This is the first large‐scale molecular and phylogenetic study analyzing HBV sequences from 28 different Malagasy areas, never sampled in the past. In this study, the most prevalent genotype/sub‐genotypes was E. Migration analysis showed a gene flow from zone 3 (rural) to zone 2 (suburban), and a greater gene flow from the middle part of Madagascar to the north than to the south. It is important to study the HBV infections in Madagascar and to monitor the potential spread of this viral strain inside this country. J. Med. Virol. 88:2138–2144, 2016 . © 2016 Wiley Periodicals, Inc.