Premium
Recent advances in understanding norovirus pathogenesis
Author(s) -
Karst Stephanie M.,
Tibbetts Scott A.
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24559
Subject(s) - norovirus , virology , tropism , biology , virus , tissue tropism , immune system , murine norovirus , disease , pathogenesis , acute gastroenteritis , microbiology and biotechnology , immunology , medicine , pathology
Noroviruses constitute a family of ubiquitous and highly efficient human pathogens. In spite of decades of dedicated research, human noroviruses remain a major cause of gastroenteritis and severe diarrheal disease around the world. Recent findings have begun to unravel the complex mechanisms that regulate norovirus pathogenesis and persistent infection, including the important interplay between the virus, the host immune system, and commensal bacteria. Herein, we will summarize recent research developments regarding norovirus cell tropism, the use of M cells, and commensal bacteria to facilitate norovirus infection, and virus, host, and bacterial determinants of persistent norovirus infections. J. Med. Virol. 88:1837–1843, 2016 . © 2016 Wiley Periodicals, Inc.