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Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals
Author(s) -
Chin Bum Sik,
Chaillon Antoine,
Mehta Sanjay R.,
Wertheim Joel O.,
Kim Gayeon,
Shin HyoungShik,
Smith Davey M.
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24523
Subject(s) - transmission (telecommunications) , epidemiology , molecular epidemiology , human immunodeficiency virus (hiv) , genotype , virology , genetic epidemiology , genetics , linkage (software) , demography , biology , medicine , gene , telecommunications , computer science , sociology
To evaluate if HIV transmission networks could be elucidated from data collected in a short time frame, 131 HIV‐1 pol sequences were analyzed which were generated from treatment‐naïve Korean individuals who were sequentially identified over 1 year. A transmission linkage was inferred when there was a genetic distance <1.5% and a total of 16 clusters, involving 39/131 (29.8%), were identified. Younger age and heterosexual exposure were independently related with clustering in the inferred network, which demonstrated that molecular epidemiology with currently generated data (i.e., drug resistance genotypes) can be used to identify local transmission networks, even over a short timeframe. J. Med. Virol. 88:1832–1835, 2016 . © 2016 Wiley Periodicals, Inc.