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Seroprevalence of antibodies against GII.4 norovirus among children in Pune, India
Author(s) -
Kulkarni Ruta,
Lole Kavita,
Chitambar Shobha D.
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24495
Subject(s) - norovirus , seroprevalence , antibody , titer , virology , medicine , biology , serology , immunology , virus
This study reports the seroprevalence of antibodies against GII.4 norovirus among children (≤5 years) in Pune, India. Of 191 serum specimens, 98 (51.3%) tested positive with 61, 34 and 3 having IgG, IgG‐IgA and IgG‐IgA‐IgM, respectively. Histoblood group antigen (HBGA)‐blocking antibodies were detected in 33 of the 54 tested positive specimens. IgG and blocking antibody prevalence and titer varied with age and was lowest among children aged 6–23 months. Antibody‐positive children, suggesting past norovirus exposure, showed significantly lower faecal norovirus RNA detection rate than antibody‐negative children. Further investigation of the seroepidemiology of norovirus infections in India is warranted. J. Med. Virol. 88:1636–1640, 2016 . © 2016 Wiley Periodicals, Inc.