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Identification of recombination in the NS1 and VPs genes of parvovirus B19
Author(s) -
Shen Hongxing,
Zhang Wen,
Wang Hua,
Shao Shihe
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24471
Subject(s) - virology , parvovirus , parvoviridae , identification (biology) , gene , biology , recombination , genetics , virus , botany
Human parvovirus B19 (B19V), a member of the genus Erythrovirus of the family Parvoviridae , is a pathogenic virus distributed worldwide in the human population. In this study, we performed phylogenetic and recombination analysis of B19V based on the available nonstructural gene (NS1) and capsid proteins (VPs) genes in GenBank. Results indicated that recombination occurred between genotypes 3 and 1, leading to the recombinant cluster genotype 2. Other three inter‐genotype recombination events were also discovered. Moreover, our results showed that among the four recombinant events in the present study, all of the major parents belonged to genotype 1, the minor parents were from genotypes 3 or 2, and all of the recombinants belonged to genotype 2. These recombinant events were confirmed by SimPlot Program and phylogenetic analysis. J. Med. Virol. 88:1457–1461, 2016 . © 2016 Wiley Periodicals, Inc.