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Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis
Author(s) -
AraújoMariz Carolline,
Lopes Edmundo Pessoa,
Ximenes Ricardo A.A.,
Lacerda Heloísa R.,
MirandaFilho Demócrito B.,
Montarroyos Ulisses R.,
Barreto Silvana,
Salustiano Daniela Medeiros,
Albuquerque Maria Fátima Pessoa Militão
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24432
Subject(s) - medicine , tuberculosis , hepatitis b virus , serology , odds ratio , hepatitis c virus , virology , immunology , hepatitis b , confidence interval , logistic regression , viral disease , hepatitis c , antibody , virus , pathology
Infection with hepatitis B virus (HBV) and C virus (HCV) are common in patients with HIV/AIDS and tuberculosis (TB). This is a cross‐sectional study with patients infected with HIV/AIDS and active TB in Recife, Brazil, aiming to verify the prevalence of markers for HBV: antibody to hepatitis B core antigen (anti‐HBc); and HCV: antibody to hepatitis C virus (anti‐HCV) by chemiluminescence, and to identify the frequency of associated factors. Data were collected through questionnaires, and blood was drawn from patients for analysis. We used the chi‐square test and the Fisher exact test when necessary. We conducted a bivariate logistic regression analysis and the magnitude of the associations was expressed as odds ratio (OR) with a confidence interval of 95%. Among 166 patients studied with HIV/AIDS and active TB, anti‐HBc was positive in 61 patients [36.7%; 95%CI (29.4–44.6%)] and anti‐HCV in 11[6.6%; 95%CI (3.4–11.5%)]. In the logistic regression analysis, male sex, and age ≥40 years were independent factors associated with the occurrence of anti‐HBc. In conclusion, we verified a high frequency of HBV contact marker and a low frequency of HCV markers in patients with HIV/AIDS and TB in Recife. J. Med. Virol. 88:996–1002, 2016 . © 2015 Wiley Periodicals, Inc.