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The role of human papillomavirus in head and neck squamous cell carcinoma: A case control study on a southern Chinese population
Author(s) -
Chor Josette S.Y.,
Vlantis Alexander C.,
Chow TamLin,
Fung SiuChung,
Ng Fiona Y.H.,
Lau ChiHung,
Chan Amy B.W.,
Ho LuenCheung,
Kwong WingHang,
Fung Mandy N.S.,
Lam Eddy W.H.,
Mak KwongLin,
Lam Holly C.Y.,
Kok Amy S.Y.,
Ho Wendy C.S.,
Yeung Apple C.M.,
Chan Paul K.S.
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24405
Subject(s) - head and neck squamous cell carcinoma , odds ratio , medicine , population , hpv infection , oncology , larynx , cancer , cancer research , head and neck cancer , cervical cancer , environmental health , surgery
HPV plays a role in the development of a portion of head and neck squamous cell carcinoma (HNSCC), but only limited information on its role in southern Chinese population is available. A multicenter case‐control study was conducted. HPV type, viral integration, E6/7 mRNA expression status, and TP53 mutation were determined. A total of 228 HNSCC were recruited including 137 (60.1%) oral SCC, 34 (14.9%) oropharyngeal SCC, 31 (13.6%) laryngeal SCC, 21 (9.2%) hypopharyngeal SCC, and 5 (2.2%) lip and paranasal sinus SCC. High‐risk HPV infection was found in 7.5% (17/228) of HNSCC, but only a small proportion of samples had evidence of viral integration (5.3%, 12/228) or E6/7 mRNA expression (4.4%, 10/228). HPV infection with oncogenic phenotype (integration and E6/7 mRNA expression) was significantly more common in oropharyngeal SCC than controls (9/34, 26.5% vs. 0/42, 0.0%, P < 0.001). Smoking showed a significant association with HNSCC, oropharyngeal SCC, and laryngeal SCC. TP53 mutation was associated with HNSCC ( P < 0.001). Older age, TP53 mutation, and HPV16 infection with oncogenic phenotypes were independently associated factors for HNSCC with odds ratios of 1.03 (1.02–1.05), 3.38 (1.71–6.66), and 9.19 (1.13–74.68), respectively. High‐risk HPV infection of head and neck mucosa is not uncommon in the Hong Kong population. This study found that 26–30% of oropharyngeal carcinoma was associated with HPV infection, mostly HPV16, and that smoking which predisposes to TP53 mutations was another important risk factor. J. Med. Virol. 88:877–887, 2016 . © 2015 Wiley Periodicals, Inc.