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Mix‐breeding with HEV‐infected swine induced inapparent HEV infection in SPF rabbits
Author(s) -
Liu Lin,
Wang Lin,
Xia Junke,
Zhang Yulin,
Zeng Hang,
Liu Peng,
Zou Qinghua,
Wang Ling,
Zhuang Hui
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24374
Subject(s) - seroconversion , biology , virology , feces , transmission (telecommunications) , caliciviridae , hepatitis e virus , antibody , virus , viral disease , immunology , microbiology and biotechnology , genotype , biochemistry , electrical engineering , gene , engineering
Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross‐species transmission of sHEV to rabbits, the pigs with HEV infection were farmed along with SPF rabbits in the same enclosed space. Five of 10 rabbits had seroconversion for anti‐HEV antibody from the third week after mix‐breeding. However, HEV RNA remained undetectable in feces, serum, liver and bile of the ten rabbits; and no obvious elevation of ALT was observed. The results possibly suggested that sHEV might lead to an inapparent infection of SPF rabbits by fecal‐oral route. J. Med. Virol. 88:681–685, 2016 . © 2015 Wiley Periodicals, Inc.