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Immunogenicity and sustainability of the immune response in Brazilian HIV‐1‐infected individuals vaccinated with inactivated triple influenza vaccine
Author(s) -
Souza Thiago Moreno L.,
SantiniOliveira Marilia,
Martorelli Andressa,
Luz Paula M.,
Vasconcellos Mauricio T.L.,
GiacoiaGripp Carmem B.W.,
Morgado Mariza,
Nunes Estevão P.,
Lemos Alberto S.,
Ferreira Ana C.G.,
Moreira Ronaldo I.,
Veloso Valdiléa G.,
Siqueira Marilda,
Grinsztejn Beatriz,
Camacho Luiz A.B.
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24351
Subject(s) - vaccination , seroconversion , medicine , immunogenicity , virology , immunology , influenza vaccine , immunization , inactivated vaccine , immune system , virus
HIV‐infected individuals have a higher risk of serious illnesses following infection by infection with influenza. Although anti‐influenza vaccination is recommended, immunosuppression may limit their response to active immunization. We followed‐up a cohort of HIV‐infected individuals vaccinated against influenza to assess the immunogenicity and sustainability of the immune response to vaccination. Individuals were vaccinated 2011 with inactivated triple influenza vaccine (TIV), and they had received in 2010 the monovalent anti‐A(H1N1)pdm09 vaccine. The sustainability of the immune response to A(H1N1)pdm09 at 12 months after monovalent vaccination fell, both in individuals given two single or two double doses. For these individuals, A(H1N1)pdm09 component from TIV acted as a booster, raising around 40% the number of seroprotected individuals. Almost 70% of the HIV‐infected individuals were already seroprotected to A/H3N2 at baseline. Again, TIV boosted over 90% the seroprotection to A/H3N2. Anti‐A/H3N2 titers dropped by 20% at 6 months after vaccination. Pre‐vaccination seroprotection rate to influenza B (victoria lineage) was the lowest among those tested, seroconversion rates were higher after vaccination. Seroconversion/protection after TIV vaccination did not differ significantly across categories of clinical and demographic variables. Anti‐influenza responses in Brazilian HIV‐infected individuals reflected both the previous history of virus circulation in Brazil and vaccination. J. Med. Virol. 88:426–436, 2016 . © 2015 Wiley Periodicals, Inc.