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Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother
Author(s) -
Zavattoni Maurizio,
Rustico Mariangela,
Tassis Beatrice,
Lombardi Giuseppina,
Furione Milena,
Piralla Antonio,
Baldanti Fausto
Publication year - 2016
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24313
Subject(s) - asymptomatic , fetus , gestation , cytomegalovirus , medicine , human cytomegalovirus , gestational age , pregnancy , obstetrics , betaherpesvirinae , viral disease , herpesviridae , immunology , biology , virus , genetics
Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses. J. Med. Virol. 88:120–126, 2016 . © 2015 Wiley Periodicals, Inc.