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Pteropine orthoreovirus infection among out‐patients with acute upper respiratory tract infection in Malaysia
Author(s) -
Voon Kenny,
Tan Yeh Fong,
Leong Pooi Pooi,
Teng Cheong Lieng,
Gunnasekaran Rajasekaran,
Ujang Kamsiah,
Chua Kaw Bing,
Wang LinFa
Publication year - 2015
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24304
Subject(s) - sore throat , upper respiratory tract infection , virology , incidence (geometry) , respiratory tract infections , respiratory tract , viral infection , throat , virus , biology , medicine , immunology , respiratory system , physics , anatomy , optics
This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyngeal swabs, our study demonstrates that PRV is among one of the common causative agents of acute URTI with cough and sore throat as the commonest presenting clinical features. Phylogenetic analysis on partial major outer and inner capsid proteins shows that these PRV strains are closely related to Melaka and Kampar viruses previously isolated in Malaysia. Further study is required to determine the public health significance of PRV infection in Southeast Asia, especially in cases where co‐infection with other pathogens may potentially lead to different clinical outcomes. J. Med. Virol. 87:2149–2153, 2015 . © 2015 Wiley Periodicals, Inc.