Molecular epidemiology of an outbreak of hand, foot, and mouth disease associated with subgenotype C4a of enterovirus A71 in Nanchang, China in 2014 | Zendy

Zhou Xianfeng | Zendy; Zhu Qingxiong | Zendy; Xia Wen | Zendy; He Fenglan | Zendy; Hu Maohong | Zendy; Ni Xiansheng | Zendy; Gao Meiling | Zendy; Chen Haiying | Zendy; Chen Shengen | Zendy

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Molecular epidemiology of an outbreak of hand, foot, and mouth disease associated with subgenotype C4a of enterovirus A71 in Nanchang, China in 2014

Author(s) -

Zhou Xianfeng,

Zhu Qingxiong,

Xia Wen,

He Fenglan,

Hu Maohong,

Ni Xiansheng,

Gao Meiling,

Chen Haiying,

Chen Shengen

Publication year - 2015

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.24288

Subject(s) - outbreak , hand foot and mouth disease , virology , foot and mouth disease , enterovirus 71 , enterovirus , epidemiology , coxsackievirus , biology , c4a , genotype , veterinary medicine , medicine , virus , genetics , gene

An outbreak of hand, foot, and mouth disease was reported through hospital‐based surveillance in Nanchang, China in 2014. A total of 244 cases were reported, 176 (72.1%) cases were tested positive for enteroviruses by direct reverse transcription‐polymerase chain reaction, in which enterovirus A71 (EV‐A71), coxsackievirus A16 (CV‐A16), and untyped enteroviruses (UEV) accounted for 84.1%, 3.4%, and 12.5%, respectively. In this outbreak, children under 5 years old constituted more than 98% of the positive cases, and the ratio of male to female cases was 2.6 to 1 ( P < 0.01). Phylogenetic analysis indicated that the Nanchang EV‐A71 strains belonged to subgenotype C4a undergoing continuously evolutionary changes. J. Med. Virol. 87:2154–2158, 2015 . © 2015 Wiley Periodicals, Inc.

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