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Molecular epidemiology of an outbreak of hand, foot, and mouth disease associated with subgenotype C4a of enterovirus A71 in Nanchang, China in 2014
Author(s) -
Zhou Xianfeng,
Zhu Qingxiong,
Xia Wen,
He Fenglan,
Hu Maohong,
Ni Xiansheng,
Gao Meiling,
Chen Haiying,
Chen Shengen
Publication year - 2015
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24288
Subject(s) - outbreak , hand foot and mouth disease , virology , foot and mouth disease , enterovirus 71 , enterovirus , epidemiology , coxsackievirus , biology , c4a , genotype , veterinary medicine , medicine , virus , genetics , gene
An outbreak of hand, foot, and mouth disease was reported through hospital‐based surveillance in Nanchang, China in 2014. A total of 244 cases were reported, 176 (72.1%) cases were tested positive for enteroviruses by direct reverse transcription‐polymerase chain reaction, in which enterovirus A71 (EV‐A71), coxsackievirus A16 (CV‐A16), and untyped enteroviruses (UEV) accounted for 84.1%, 3.4%, and 12.5%, respectively. In this outbreak, children under 5 years old constituted more than 98% of the positive cases, and the ratio of male to female cases was 2.6 to 1 ( P < 0.01). Phylogenetic analysis indicated that the Nanchang EV‐A71 strains belonged to subgenotype C4a undergoing continuously evolutionary changes. J. Med. Virol. 87:2154–2158, 2015 . © 2015 Wiley Periodicals, Inc.