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Human cytomegalovirus inhibits apoptosis involving upregulation of the antiapoptotic protein Bag‐1
Author(s) -
Li Hai Ping,
Yuan Cong Ling,
Zho Ying Chun
Publication year - 2015
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24259
Subject(s) - human cytomegalovirus , apoptosis , mapk/erk pathway , downregulation and upregulation , virology , biology , cytomegalovirus , embryonic stem cell , programmed cell death , immunology , virus , signal transduction , microbiology and biotechnology , herpesviridae , viral disease , genetics , gene
Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised individuals and is recognized as a major viral cause of birth defects. HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. Apoptosis is an innate cellular defense response to viral infection. HCMV can block apoptosis in various cell types. Here we show that HCMV promotes survival of human embryonic lung fibroblasts by activating of MAPK/ERK signaling pathway. Bag‐1 is up‐regulated in a MAPK/ERK‐dependent fashion in infected cells. Depletion of Bag‐1 suppresses the antiapoptotic effect of HCMV. Taken together, these data indicate that Bag‐1 up‐regulation is required to maintain apoptosis resistance in HCMV infected cells. J. Med. Virol. 87:1953–1959, 2015 . © 2015 Wiley Periodicals, Inc.