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Full genome analysis of a European‐type genotype 3 hepatitis E virus variant obtained from a Japanese patient with autochthonous acute hepatitis E
Author(s) -
Takeuchi Suguru,
Yamazaki Yuichi,
Sato Ken,
Takizawa Daichi,
Yamada Masanobu,
Okamoto Hiroaki
Publication year - 2015
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24191
Subject(s) - hypervariable region , virology , genotype , genome , strain (injury) , biology , whole genome sequencing , genetics , hepatitis c virus , sequence analysis , virus , hepatitis , hepatitis e virus , gene , anatomy
A unique European‐type HEV strain (HE‐JA12‐0725) classifiable into subgenotype 3f was recovered from a 66‐year‐old Japanese female with autochthonous acute hepatitis E, and its entire genomic sequence was determined and characterized. The HE‐JA12‐0725 strain shared the highest identity of 92.7% with a Spanish swine isolate (EU723514) over the entire genome and possessed a long hypervariable region sequence of 111 amino acids, identical to the 3f strains of European origin. The patient had consumed pork liver obtained via home delivery in Japan approximately two months before the disease onset. These results suggest the circulation of rare 3f HEV strains in Japan. J. Med. Virol. 87:1067–1071, 2015 . © 2015 Wiley Periodicals, Inc.