Premium
Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country
Author(s) -
RodríguezMartínez Carlos E.,
Rodríguez Diego Andrés,
Nino Gustavo
Publication year - 2015
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24139
Subject(s) - medicine , respiratory system , epidemiology , virus , respiratory infection , comorbidity , pediatrics , retrospective cohort study , pneumovirinae , cohort , adenovirus infection , cohort study , immunology , virology , viral disease , paramyxoviridae
There is growing evidence suggesting greater severity and worse outcomes in children with mixed as compared to single respiratory virus infections. However, studies that assess the risk factors that may predispose a child to a mixture of respiratory syncytial virus (RSV) and adenoviral infections, are scarce. In a retrospective cohort study, the study investigated the epidemiology of RSV and adenovirus infections and predictors of mixed RSV‐adenoviral infections in young children hospitalized with acute lower respiratory infection in Bogota, Colombia, South America, over a 2‐year period 2009–2011. Of a total of 5,539 children admitted with a diagnosis of acute lower respiratory infection, 2,267 (40.9%) who were positive for RSV and/or adenovirus were selected. Out the total number of cases, 1,416 (62.5%) infections occurred during the 3‐month period from March to May, the first rainy season of Bogota, Colombia. After controlling for gender, month when the nasopharyngeal sample was taken, and other pre‐existing conditions, it was found that an age greater than 6 months (OR:1.74; CI 95%:1.05–2.89; P = 0.030) and malnutrition as a comorbidity (OR:9.92; CI 95%:1.01–100.9; P = 0.049) were independent predictors of mixed RSV‐adenoviral infections in the sample of patients. In conclusion, RSV and adenovirus are significant causes of acute lower respiratory infection in infants and young children in Bogota, Colombia, especially during the first rainy season. The identified predictors of mixed RSV‐adenoviral infections should be taken into account when planning intervention, in order to reduce the burden of acute lower respiratory infection in young children living in the country. J. Med. Virol. 87:774–781, 2015 . © 2015 Wiley Periodicals, Inc.