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MBL2 polymorphisms in women with atypical squamous cells of undetermined significance
Author(s) -
Zupin Luisa,
Polesello Vania,
Casalicchio Giorgia,
Freato Nadia,
Maestri Iva,
Comar Manola,
Crovella Sergio,
Segat Ludovica
Publication year - 2015
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24080
Subject(s) - clinical significance , genotype , allele , immunology , biology , mannan binding lectin , hpv infection , cervical cancer , exon , virology , gene , medicine , cancer , pathology , lectin , genetics
Infection with high risk Human papillomavirus (HPV) is the main known cause of cervical cancer. HPV induces different grades of lesions: among them, Atypical squamous cells of undetermined significance are abnormal lesions that could evolve in pre‐cancer lesions or spontaneously regress. The mannose binding lectin (MBL) is an innate immunity serum protein also found in cervico‐vaginal mucosa, whose expression is known to be affected by polymorphisms in exon 1 and promoter of the MBL2 gene. In the present study the possible association between MBL2 functional polymorphisms and susceptibility to develop atypical squamous cells of undetermined significance was investigated in a group of women from North‐East of Italy, stratified for HPV infection status. The MBL2 D and O alleles and the deficient producer combined genotypes, responsible for low MBL production, were more represented among atypical squamous cells of undetermined significance positive women than healthy controls and the results were confirmed when only HPV negative samples were considered. These results suggest a possible involvement of MBL2 functional polymorphisms in atypical squamous cells of undetermined significance susceptibility. J. Med. Virol. 87:851–859, 2015 . © 2015 Wiley Periodicals, Inc.