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Presence of Betapapillomavirus in Kaposi sarcoma lesions
Author(s) -
Murahwa Alltalents T.,
Muchemwa Faith C.,
Duri Kerina,
Borok Margaret Z.,
Kanyera Russell B.,
Manhanzva Monalisa T.,
Mapingure Munyaradzi P.,
StrayPedersen Babill
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23944
Subject(s) - carcinogenesis , virology , sarcoma , virus , kaposi's sarcoma , biology , human herpesvirus , human papillomavirus , viral disease , pathology , medicine , cancer , genetics
Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta‐HPV infections in skin lesions, an unexpected occurrence of HPV DNA was found in KS lesions of HIV infected individuals. Of the 18 KS cases included in the study 16 (89%) had HPV DNA detected. The most common Betapapillomavirus types were HPV14 [15 cases (83.3%)], HPV12 [8 cases (44.4%)], and HPV24 [7 cases (39%)]. Multiple Beta‐HPV types were detected in 10 (62.5%) of the participants with HPV DNA positive lesions; of these 7 had a CD4+ count below 350 cells/µl and 3 had CD4+ counts above 350 cells/µl. The presence of Beta‐HPV DNA in KS lesions is a newly described phenomenon. Further studies to elucidate the role of Beta‐HPV in KS need to be conducted as it is possible that HHV 8 may not be the solitary viral carcinogen in KS tumorigenesis. J. Med. Virol. 86:1556–1559, 2014 . © 2014 Wiley Periodicals, Inc.