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Genome‐wide association study of HPV‐associated cervical cancer in Japanese women
Author(s) -
Miura Kiyonori,
Mishima Hiroyuki,
Kinoshita Akira,
Hayashida Chisa,
Abe Shuhei,
Tokunaga Katsushi,
Masuzaki Hideaki,
Yoshiura Kohichiro
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23943
Subject(s) - cervical cancer , single nucleotide polymorphism , virus , virology , human papillomavirus , hpv infection , cancer , genome , genome wide association study , medicine , biology , genotype , genetics , gene
One of the important factors influencing the development of uterine cervical cancer is human papillomavirus infection in women. Usually, the infecting papillomavirus is eliminated from individuals; however, some retain the virus and this is believed to lead to the development of uterine cervical cancer. It is possible that virus elimination or persistent infection depends on an individual's genetic background. To identify single nucleotide polymorphisms associated with susceptibility to persistent infection or cervical cancer, a genome‐wide association study was performed on 226 cases and 186 controls. Some of the single nucleotide polymorphisms showed a P ‐value < 10 −5 ; however, no polymorphisms that were significantly associated with susceptibility to cervical cancer were identified. J. Med. Virol. 86:1153–1158, 2014 . © 2014 Wiley Periodicals, Inc.