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The interaction of a single‐nucleotide polymorphism with age on response to interferon‐α and ribavirin therapy in female patients with hepatitis C infection
Author(s) -
Nishino Jo,
Sugiyama Masaya,
Nishida Nao,
Tokunaga Katsushi,
Mizokami Masashi,
Mano Shuhei
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23939
Subject(s) - ribavirin , genotype , single nucleotide polymorphism , snp , virology , hepatitis c virus , interferon , medicine , hepatitis c , pegylated interferon , polymorphism (computer science) , immunology , virus , biology , genetics , gene
Older female patients exhibit a poor response to the current standard treatment for hepatitis C, interferon‐α, and ribavirin (PEG‐IFN‐α/RBV). In this study, we reported that the combination of age and the genotype of a novel SNP can predict response to standard treatment ( P = 7.31 × 10 −8 ). The model incorporating genotype of the novel SNP, rs1287948, predicts response more accurately (AUC = 0.934; 95% CI = 0.881–0.988) in women as compared with the model using age and the previously identified SNP, rs8099917. J. Med. Virol. 86:1130–1133, 2014 . © 2014 Wiley Periodicals, Inc.