The interaction of a single‐nucleotide polymorphism with age on response to interferon‐α and ribavirin therapy in female patients with hepatitis C infection

Older female patients exhibit a poor response to the current standard treatment for hepatitis C, interferon‐α, and ribavirin (PEG‐IFN‐α/RBV). In this study, we reported that the combination of age and the genotype of a novel SNP can predict response to standard treatment ( P  = 7.31 × 10 −8 ). The model incorporating genotype of the novel SNP, rs1287948, predicts response more accurately (AUC = 0.934; 95% CI = 0.881–0.988) in women as compared with the model using age and the previously identified SNP, rs8099917. J. Med. Virol. 86:1130–1133, 2014 . © 2014 Wiley Periodicals, Inc.