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Recent insights into hepatitis B virus–host interactions
Author(s) -
Ezzikouri Sayeh,
Ozawa Makoto,
Kohara Michinori,
Elmdaghri Naima,
Benjelloun Soumaya,
TsukiyamaKohara Kyoko
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23916
Subject(s) - hepatitis b virus , virology , biology , virus , genome , viral replication , host factors , viral life cycle , hepatitis d virus , host (biology) , hepadnaviridae , genetics , gene , hbsag
Hepatitis B virus (HBV) poses a threat to global public health mainly because of complications of HBV‐related chronic liver disease. HBV exhibits a narrow host range, replicating primarily in hepatocytes by a still poorly understood mechanism. For the generation of progeny virions, HBV depends on interactions with specific host factors through its life cycle. Revealing and characterizing these interactions are keys to identifying novel antiviral targets, and to developing specific treatment strategies for HBV patients. In this review, recent insights into the HBV–host interactions, especially on virus entry, intracellular trafficking, genome transcription and replication, budding and release, and even cellular restriction factors were reviewed. J. Med. Virol. 86:925–932, 2014 . © 2014 Wiley Periodicals, Inc.