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Cytokine and chemokine responses in the blood and cerebrospinal fluid of patients with human herpesvirus 6B‐associated acute encephalopathy with biphasic seizures and late reduced diffusion
Author(s) -
Kawamura Yoshiki,
Yamazaki Yumie,
Ohashi Masahiro,
Ihira Masaru,
Yoshikawa Tetsushi
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23788
Subject(s) - cerebrospinal fluid , medicine , encephalopathy , chemokine , immunology , cytokine , pathogenesis , human herpesvirus 6 , pathophysiology , encephalitis , monokine , viral encephalitis , interleukin , inflammation , virus , viral disease , herpesviridae
Acute encephalopathy with biphasic seizures and late reduced diffusion has become increasingly common among various types of human herpesvirus 6B (HHV‐6B) encephalitis at the time of primary viral infection. The aim of the present study is to explore the pathophysiology of HHV‐6B‐associated acute encephalopathy with biphasic seizures and late reduced diffusion. Five cytokines and five chemokines were measured in serum and cerebrospinal fluid (CSF) obtained from 12 HHV‐6B‐associated acute encephalopathy with biphasic seizures and late reduced diffusion patients and 19 control exanthem subitum (without complications) patients. Serum interleukin (IL)‐10 ( P = 0.007) and IL‐8 ( P = 0.025) were significantly higher in the patients with the disease than controls. Serum IL‐1β ( P = 0.034) and monocyte chemoattractant protein (MCP)‐1 ( P = 0.002) were significantly higher in the controls than patients with the disease. In patients with the disease, IL‐10 ( P = 0.012), regulated on activation normal T cell expressed and secreted (RANTES; P = 0.001), and monokine induced by interferon γ (MIG; P = 0.001) were significantly higher in serum than CSF, meanwhile IL‐6 ( P = 0.034), IL‐8 ( P = 0.034), and MCP‐1 ( P = 0.001) were significantly higher in CSF than serum. Additionally, serum IL‐10 was significantly higher in the disease patients with sequelae than those without sequelae ( P = 0.016). Several cytokines and chemokines may be associated with the pathogenesis of acute encephalopathy with biphasic seizures and late reduced diffusion. Moreover, the regulation of cytokine networks appears to be different between peripheral blood (systemic) and central nervous system. J. Med. Virol. 86:512–518, 2014 . © 2013 Wiley Periodicals, Inc.