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Unusual presentation of Epstein–Barr virus hepatitis treated successfully with valganciclovir
Author(s) -
Cauldwell Katrine,
Williams Roger
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23766
Subject(s) - valganciclovir , mononucleosis , virology , serology , medicine , hepatitis , cytomegalovirus , virus , liver biopsy , hepatitis a , biopsy , immunology , herpesviridae , antibody , pathology , viral disease , ganciclovir , human cytomegalovirus
Abstract Described is the case of a 21‐year‐old male patient who presented with a severe Epstein–Barr virus (EBV) hepatitis. The initial diagnosis was challenging, as the patient did not have the typical features of the mononucleosis syndrome and despite the severity of the hepatitis, the initial serology was negative. In addition the liver biopsy did not show the mononuclear cell infiltration typically seen in EBV hepatitis. Later, measurements of EBV DNA showed high titers and the patient received a course of oral valganciclovir, following which he made a rapid clinical and serological response. This case describes an unusual presentation of EBV hepatitis, and adds to the body of evidence supporting its treatment with valganciclovir. J. Med. Virol. 86:484–486, 2014 . © 2013 Wiley Periodicals, Inc.