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Human papillomavirus infection in women in four regions of Senegal
Author(s) -
Mbaye El Hadji Seydou,
Gheit Tarik,
Dem Ahmadou,
McKayChopin Sandrine,
ToureKane Ndeye Coumba,
Mboup Souleymane,
Tommasino Massimo,
Sylla Bakary S.,
Boye Cheikh Saad Bouh
Publication year - 2014
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23719
Subject(s) - genotyping , medicine , cervical cancer , human papillomavirus , genotype , hpv infection , virology , population , hpv vaccines , gynecology , cancer , demography , biology , genetics , environmental health , gene , sociology
Cervical cancer is the most frequent cancer among women in Senegal. However, there are few data concerning the human papillomavirus (HPV) types inducing neoplasia and cervical cancers and their prevalence in the general population of Senegal. The aim of this study is to determine the prevalence of HPV infection in Senegalese women aged 18 years and older in Dakar Region and three other regions. Cervical samples were collected from 498 women aged 18–80 years (mean, 42.1 years) in Dakar Region. Also, 438 samples were collected from three other regions: Thiès, Saint‐Louis, and Louga. The samples were screened for 21 HPV genotypes using an HPV type‐specific E7 PCR bead‐based multiplex genotyping assay (TS‐MPG). The prevalence of high risk (HR)‐HPV in Dakar Region was 17.4%. HPV 52 (3.2%) was the most prevalent HPV type, followed by HPV 31 (3.0%) and HPV 16, 45, and 53 (all 2.8%). In the Thiès, Saint‐Louis, and Louga Regions, the prevalence of HR‐HPV was 23.2%, 13.1%, and 19.4%, respectively. The study revealed the specificity of HPV prevalence in Dakar Region and other regions of Senegal. The observed patterns show some differences compared with other regions of the world. These findings raise the possibility that, in addition to HPV 16 and HPV 18, other HPV types should be considered for a vaccination program in Senegal. However, additional studies to determine the HPV type distribution in cervical cancer specimens in Senegal are required to further corroborate this hypothesis. J. Med. Virol. 86:248–256, 2014 . © 2013 Wiley Periodicals, Inc.