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Detection of merkel cell polyomavirus in oral samples of renal transplant recipients without Merkel cell carcinoma
Author(s) -
Baez Camila Freze,
Guimarães Maria Angélica A. M.,
Martins Rosângela A. G.,
Zalona Ana Carolina Jonard,
Cossatis João José,
Zalis Mariano Gustavo,
Cavalcanti Silvia Maria Baeta,
Varella Rafael Brandão
Publication year - 2013
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23687
Subject(s) - merkel cell polyomavirus , merkel cell carcinoma , polyomavirus infections , merkel cell , saliva , biology , gingivitis , pathology , virology , carcinoma , transplantation , immunology , bk virus , kidney transplantation , medicine , biochemistry , dentistry
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine cancer, with approximately 80% of cases associated with Merkel cell polyomavirus (MCPyV). The lack of information concerning its occurrence in non‐MCC immunosuppressed populations led to the investigation of MCPyV DNA in saliva and oral biopsies from 60 kidney allograft recipients and 75 non‐transplanted individuals (control group). In contrast to herpesviruses, which was also investigated (CMV, HHV‐6A, and B, HHV‐7) MCPyV was detected predominantly in patients with oral lesions (gingivitis and/or periodontitis) of both transplanted and non‐transplanted groups ( P = 0.016) and in the saliva of the transplanted group ( P = 0.009). MCPyV co‐detection with CMV ( P = 0.048), and HHV‐6 ( P = 0.020) in the saliva of transplanted patients requires further investigation on a possible role of co‐infection. J Med. Virol. 85:2016–2019, 2013 . © 2013 Wiley Periodicals, Inc.