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Mannose binding lectin and mannose binding lectin‐associated serine protease‐2 genes polymorphisms in human T‐lymphotropic virus infection
Author(s) -
Coelho Antonio Victor Campos,
Brandão Lucas André Cavalcanti,
Guimarães Rafael Lima,
Loureiro Paula,
de Lima Filho José Luiz,
de Alencar Luiz Cláudio Arraes,
Crovella Sergio,
Segat Ludovica
Publication year - 2013
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23656
Subject(s) - mannan binding lectin , masp1 , lectin , virology , mannose , ficolin , serine protease , biology , cd69 , gene , serine , virus , microbiology and biotechnology , protease , immunology , genetics , biochemistry , enzyme , immune system , t cell , il 2 receptor
Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T‐lymphotropic virus, HTLV‐1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP‐2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV‐1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV‐1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV‐1 infection, and provides further evidence of an association between the MBL2 gene and HTLV‐1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV‐1 infection. J Med. Virol. 85:1829–1835, 2013 . © 2013 Wiley Periodicals, Inc.