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Seroprevalence of Seasonal and Pandemic Influenza A in Kuala Lumpur, Malaysia in 2008–2010
Author(s) -
Sam IChing,
Shaw Robert,
Chan YokeFun,
Hooi PohSim,
Hurt Aeron C.,
Barr Ian G.
Publication year - 2013
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23622
Subject(s) - seroprevalence , kuala lumpur , pandemic , incidence (geometry) , pandemic influenza , medicine , virology , seasonal influenza , veterinary medicine , demography , geography , covid-19 , immunology , serology , antibody , business , physics , disease , marketing , sociology , infectious disease (medical specialty) , optics
Relatively little is known about the burden of influenza in tropical countries. The seroprevalence of pandemic influenza A (H1N1) 2009, seasonal H1N1 and H3N2 was determined in Kuala Lumpur, Malaysia. Pre‐ and post‐pandemic residual laboratory sera were tested by hemagglutination‐inhibition. The seroprevalence of A(H1N1)pdm09 increased from 3.7% pre‐pandemic to 21.9% post‐pandemic, giving an overall cumulative incidence of 18.1% (95% CI, 13.8–22.5%), mainly due to increases in those <5, 5–17, and 18–29 years old. In contrast with findings from USA, Europe, and Australia, pre‐existing seroprevalence to A(H1N1)pdm09 was low at 5.6% in the elderly age group of >55 years. A(H1N1)pdm09 affected almost a third of those <30 years in Kuala Lumpur. Pre‐pandemic seroprevalence was 14.7% for seasonal H1N1 and 21.0% for H3N2, and these rates did not change significantly after the pandemic. Seasonal and pandemic influenza cause a considerable burden in tropical Malaysia, particularly in children and young adults. J. Med. Virol. 85:1420–1425, 2013 . © 2013 Wiley Periodicals, Inc.