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Monitoring of KI and WU polyomaviruses in hematopoietic stem cell transplant patients
Author(s) -
Porrovecchio Rosa,
BabakirMina Muhammed,
Rapanotti Maria Cristina,
Arcese William,
Perno Carlo Federico,
Ciotti Marco
Publication year - 2013
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23565
Subject(s) - conditioning regimen , stem cell , immunology , virology , hematopoietic stem cell , bone marrow , hematopoietic stem cell transplantation , bone marrow transplant , biology , jc virus , haematopoiesis , medicine , virus , bone marrow transplantation , progressive multifocal leukoencephalopathy , genetics
Abstract Primary infection with KIPyV and WUPyV polyomaviruses occurs early in childhood followed by lifelong persistence in the body. Polyomavirus reactivation can occur in the presence of impaired immunity as in hematological malignancies or during immunosuppresssion induced by medications. In this study, reactivation of KIPyV and WUPyV was monitored by conventional PCR in plasma samples of 26 stem cell transplant patients and in 26 related bone marrow donors. Plasma samples from transplant patients were collected immediately after the end of conditioning regimen and up to 270 days after transplant. All plasma samples from transplant patients were negative for KIPyV and WUPyV DNA. Instead, KIPyV DNA was detected in two bone marrow donors. There was no evidence of KIPyV transmission from the donor to the recipient. The data suggest that detection of KIPyV in plasma is sporadic and that KPIyV and WUPyV do not affect the post‐transplant clinical course. However, further studies on a larger sample size and more sensitive PCR methods are needed to confirm these observations. J. Med. Virol. 85: 1122–1124, 2013. © 2013 Wiley Periodicals, Inc.