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Epidemiological and molecular characterization of rubella virus isolated in São Paulo, Brazil during 1997–2004
Author(s) -
Figueiredo C.A.,
Oliveira M.I.,
Curti S.P.,
Afonso A.M.S.,
Frugis YU A.L.,
Araújo J.,
Oliveira D.B.,
Durigon E.L.
Publication year - 2012
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23393
Subject(s) - rubella , congenital rubella syndrome , rubella virus , virology , epidemiology , transmission (telecommunications) , medicine , genotype , pregnancy , molecular epidemiology , biology , pediatrics , measles , vaccination , genetics , gene , electrical engineering , engineering , biochemistry
Rubella virus (RV) infection during the early stages of pregnancy can lead to serious birth defects, known as the congenital rubella syndrome (CRS). In 2003, the Pan American Health Organization (PAHO) adopted a resolution calling for the elimination of rubella and the congenital rubella syndrome (CRS) in the Americas by the year 2010. Brazil will have implemented the recommended PAHO strategy for elimination and interruption of endemic rubella virus transmission. The characterization of genotypes during the final stages of rubella elimination is important for determining whether new rubella isolates represent endemic transmission or importations. Samples (blood, urine, cerebrospinal fluid, and throat swabs) collected from patients with symptoms suggestive of rubella infection in 1997–2004 were isolated in cell culture and genotyped. Twenty‐eight sequences were analyzed and two genotypes were identified: 1a and 1G. The information reported in this paper will contribute to understanding the molecular epidemiology of RV in São Paulo, Brazil. J. Med. Virol. 84:1831–1838, 2012. © 2012 Wiley Periodicals, Inc.