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Role of enterovirus infections in IgE sensitization
Author(s) -
Seiskari Tapio,
Kondrashova Anita,
Tauriainen Sisko,
Knip Mikael,
Viskari Hanna,
Haapala AnnaMaija,
Hyöty Heikki
Publication year - 2012
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.23186
Subject(s) - echovirus , enterovirus , virology , serotype , coxsackievirus , antibody , immunology , neutralization , immunoglobulin e , sensitization , enterovirus infections , enterovirus 71 , biology , medicine , virus
Among other infectious agents, enteroviruses have been associated with protection against allergic diseases. The aim of the present study was to confirm these findings using a highly sensitive and specific neutralization antibody assay and to investigate whether the protective effect is related to certain enterovirus serotypes. Antibodies against 12 enterovirus serotypes were measured in 60 children who were positive for allergen‐specific IgE and in 190 control children. Echoviruses seemed to be more protective than coxsackie‐B‐viruses and echovirus 11 had the strongest independent protective effect ( P = 0.001; OR = 0.35, 95% CI: 0.18–0.67). The results support previous observations suggesting that infections by certain enterovirus types are associated with protection against IgE sensitization. J. Med. Virol. 84:268–271, 2012. © 2011 Wiley Periodicals, Inc.