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Local treatment of HPV‐induced skin lesions by Cidofovir
Author(s) -
Stragier Ilse,
Snoeck Robert,
De Clercq Erik,
Van den Oord Joost J.,
Van Ranst Marc,
De Greef Hugo
Publication year - 2002
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.2213
Subject(s) - cidofovir , human papillomavirus , skin lesion , medicine , virology , dermatology , virus
Human papillomavirus (HPV) induced epithelial cell proliferation is responsible for a broad range of lesions. Treatment of such lesions is characterized by a high relapse rate. Four patients are described who were treated locally with cidofovir (cream 1% or injection of 2.5 mg/ml solution) for multi‐treated relapsing HPV‐associated lesions. Three of the four patients had a complete response. The fourth patient showed a clinical response in the first cycle of treatment, but new lesions appeared during four successive cycles of cidofovir. J. Med. Virol. 67:241–245, 2002. © 2002 Wiley‐Liss, Inc.