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Positive Epstein–Barr virus and cytomegalovirus IgM assays in primary HIV infection
Author(s) -
Post Jeffrey J.,
Chan Mun Khin,
Whybin L. Ross,
Shi Qin,
Rawlinson William D.,
Cunningham Philip,
Robertson Peter W.
Publication year - 2011
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.22109
Subject(s) - virology , cytomegalovirus , virus , immunoglobulin m , capsid , antibody , epstein–barr virus , herpesviridae , immunology , hepatitis b virus , biology , antigen , serology , viral disease , medicine , immunoglobulin g
We report three cases with misleading cytomegalovirus (CMV) or Epstein–Barr virus (EBV) immunoglobulin M (IgM) results during primary human immunodeficiency virus (HIV) infection. We determined the rate of positive anti‐CMV IgM assays or anti‐EBV capsid antigen IgM assays in sera from a group of well‐characterized subjects with primary HIV infection as 2.9% (1/35; 95%CI: 0.15–16.6%) for each infection. The rate of positive anti‐EBV capsid antigen IgM assays in subjects with positive hepatitis A virus IgM assays was 30% (6/20; 95%CI: 14.6–51.9%). Clinicians need to consider the limitations of IgM assays for diagnosis of herpesvirus infections, and consider testing for other infections with overlapping clinical manifestations. J. Med. Virol. 83:1406–1409, 2011. © 2011 Wiley‐Liss, Inc.