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Human metapneumovirus genotypes and severity of disease in young children (n = 100) during a 7‐year study in Dijon hospital, France
Author(s) -
Pitoiset Cécile,
Darniot Magali,
Huet Frédéric,
Aho SergeLudwig,
Pothier Pierre,
Manoha Catherine
Publication year - 2010
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21884
Subject(s) - human metapneumovirus , genotype , metapneumovirus , medicine , disease , respiratory tract infections , virology , pediatrics , respiratory system , biology , genetics , gene
Human metapneumovirus is a cause of respiratory tract infections at all ages. Our objectives were to analyze the distribution of the A and B genotypes over 7 years in Dijon and to investigate a possible association between hMPV genotypes and disease severity. During 2002–2009, we genotyped the 100 isolates from children <3 years old with hMPV. Phylogenetic analysis indicated a change in the distribution of hMPV genotype over the years. Severity was then measured by detailed clinical evaluation. The hospitalization rate was greater when genotype B was involved 72.5% versus 53.3% ( P = 0.054). Those infected with genotype B tended to have a higher clinical score, as measured by Vicente et al. 2006 ( P = 0.07). We showed that, although clinical severity is not clearly associated with hMPV genotype in this study, pathological signs on chest X‐ray were observed more often in B subgroup ( P < 0.01). J. Med. Virol. 82:1782–1789, 2010. © 2010 Wiley‐Liss, Inc.