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Prevalence of human papillomavirus genotypes in northern Taiwanese women
Author(s) -
Tsao KuoChien,
Huang ChungGuei,
Kuo YungBin,
Chang TingChang,
Sun ChienFeng,
Chang C. Allen,
Yang SuLi,
Chan ErrCheng
Publication year - 2010
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21870
Subject(s) - papanicolaou stain , cytology , cervical cancer , human papillomavirus , genotype , medicine , gynecology , population , papanicolaou test , virology , papillomaviridae , pap test , hpv infection , obstetrics , biology , cancer , cervical cancer screening , gene , pathology , genetics , environmental health
Abstract The prevalence of Human Papillomavirus (HPV) in the general population of northern Taiwan is described. A total of 343 consecutive cervical swabs from women visiting the medical center for routine gynecologic care were included. Cervical cell cytology was examined by the Papanicolaou (Pap) test, and a PCR‐based hybridization gene chip analysis was used to identify HPV genotypes. The HPV prevalence in the overall population was 32.4%. When divided into two groups according to cytology, 20.9% of women with normal cytology were HPV positive while 75.3% of women with abnormal cytology were HPV positive. Among positive samples, 68.5% were single type infections while 31.5% harbored multiple HPV types. A total of 32 types of HPV were identified; the leading five were HPV16 (5.8%), HPV58 (5.3%), HPV53 (4.1%), HPV52 (3.8%), and HPV18 (2.3%). Our results constitute baseline data and may provide important implications for future prophylactic programs. The relatively high prevalence of HPV 58, 53, and 52 among northern Taiwanese women has important implications for vaccine development. J. Med. Virol. 82:1739–1745, 2010. © 2010 Wiley‐Liss, Inc.