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Virus clearance reduces bone fracture in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus
Author(s) -
Arase Yasuji,
Suzuki Fumitaka,
Suzuki Yoshiyuki,
Akuta Norio,
Kobayashi Masahiro,
Sezaki Hitomi,
Hosaka Tetsuya,
Kawamura Yusuke,
Yatsuji Hiromi,
Hirakawa Miharu,
Ikeda Kenji,
Hsieh Shiun Dong,
Oomoto Yuki,
Amakawa Kazuhisa,
Kato Hisahito,
Kazawa Tamae,
Tsuji Hiroshi,
Kobayashi Tetsuro,
Kumada Hiromitsu
Publication year - 2010
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21691
Subject(s) - medicine , osteoporosis , hepatitis c virus , hazard ratio , liver disease , proportional hazards model , cumulative incidence , bone remodeling , gastroenterology , cohort , surgery , confidence interval , virus , immunology
Osteoporosis is often present in postmenopausal women. The aim of this retrospective cohort study was to assess the cumulative incidence and predictive factors for bone fracture after cessation of interferon (IFN) in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus (HCV). A total of 420 postmenopausal women treated with IFN monotherapy were enrolled. The mean observation period was 7.2 years. The primary goal was the development of bone fracture. Evaluation was carried out by using the Kaplan–Meier method and the Cox proportional hazards analysis. Thirty‐one out of 420 patients sustained bone fracture. The cumulative development rate of bone fracture was 3.6% at 5th year, 9.2% at 10th year, and 17.4% at 15th year. Multivariate Cox proportional hazards analysis showed that bone fracture after cessation of IFN therapy occurred when histological staging of the liver was advanced (hazard ratio (HR): 2.54; 95% confidence interval (CI) = 1.21–5.31; P = 0.013), serum albumin level was < 3.5g/dl (HR: 2.25; 95% CI = 1.10–4.59; P = 0.026), and virus clearance was not achieved (HR: 3.65; 95% CI = 1.11–12.05; P = 0.033). The results indicate that virus clearance causes a reduction of two‐thirds in the risk of bone fracture after cessation of IFN therapy in postmenopausal women with osteoporosis and chronic liver disease caused by HCV. J. Med. Virol. 82:390–395, 2010. © 2010 Wiley‐Liss, Inc.