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Detection of a new yellow fever virus lineage within the South American genotype I in Brazil
Author(s) -
de Souza Renato P.,
Foster Peter G.,
Sallum Maria Anice M.,
Coimbra Terezinha L.M.,
Maeda Adriana Y.,
Silveira Vivian R.,
Moreno Eduardo S.,
da Silva Fernanda G.,
Rocco Iray M.,
Ferreira Ivani B.,
Suzuki Akemi,
Oshiro Fabíola M.,
Petrella Selma M.C.N.,
Pereira Luiz E.,
Katz Giselda,
Tengan Cilea H.,
Siciliano Melissa M.,
dos Santos Cecília L.S.
Publication year - 2010
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21606
Subject(s) - subclade , phylogenetic tree , virology , genotype , clade , yellow fever , biology , lineage (genetic) , virus , phylogenetics , flaviviridae , genetics , gene , viral disease
Nucleotide sequences of two regions of the genomes of 11 yellow fever virus (YFV) samples isolated from monkeys or humans with symptomatic yellow fever (YF) in Brazil in 2000, 2004, and 2008 were determined with the objective of establishing the genotypes and studying the genetic variation. Results of the Bayesian phylogenetic analysis showed that sequences generated from strains from 2004 and 2008 formed a new subclade within the clade 1 of the South American genotype I. The new subgroup is here designated as 1E. Sequences of YFV strains recovered in 2000 belong to the subclade 1D, which comprises previously characterized YFV strains from Brazil. Molecular dating analyses suggested that the new subclade 1E started diversifying from 1D about 1975 and that the most recent 2004–2008 isolates arose about 1985. J. Med. Virol. 82:175–185, 2010. © 2009 Wiley‐Liss, Inc.