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Correlation between HIV‐1 seropositivity and prevalence of a γ‐secretase polymorphism in two distinct ethnic populations
Author(s) -
van Loo Karen M.J.,
van Schijndel Jessica E.,
van Zweeden Martine,
van Manen Daniëlle,
Trip Mieke D.,
Petersen Desiree C.,
Schuitemaker Hanneke,
Hayes Vanessa M.,
Martens Gerard J.M.
Publication year - 2009
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21601
Subject(s) - snp , biology , virology , single nucleotide polymorphism , human immunodeficiency virus (hiv) , polymorphism (computer science) , genotype , allele , immunology , virus , genetics , gene
Susceptibility for human immunodeficiency virus type 1 (HIV‐1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the γ‐secretase pathway may be associated with an individual's susceptibility to infection. A functional single‐nucleotide polymorphism (SNP) in the γ‐secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV‐1 infection. The SNP showed a tendency for association with HIV‐1 infection in a Xhosa indigenous South African Bantu study ( P = 0.087), and associated significantly in a Caucasian Dutch study ( P = 0.049). Together, the results suggest a role for the γ‐secretase pathway in susceptibility to HIV‐1 infection. J. Med. Virol. 81:1847–1851, 2009. © 2009 Wiley‐Liss, Inc.
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