Premium
Cytokine responses in a severe case of glandular fever treated successfully with foscarnet combined with prednisolone and intravenous immunoglobulin
Author(s) -
Ma Christine,
Wong Chun K.,
Wong Bonnie C.K.,
Chan K.C. Allen,
Lun Samantha W.M.,
Lee Nelson,
Wu Justin,
Cockram Clive S.,
Chan Paul K.S.,
Tang Julian W.
Publication year - 2009
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21383
Subject(s) - foscarnet , prednisolone , immunology , medicine , antibody , virology , valaciclovir , immune system , viral load , virus , hepatosplenomegaly , herpesviridae , viral disease , disease
Abstract Viral loads and cytokine responses Epstein–Barr virus (EBV) were measured in an 18‐year‐old boy with severe glandular fever complicated by a mild anaemia, severe thrombocytopaenia and neutropaenia. Hepatosplenomegaly was detected by abdominal ultrasound in the presence of significant hepatitis. Cytokine testing demonstrated elevated cell‐mediated Th1 (IFN‐γ, IL‐12, sTNFR1, CXCL10, CXCL9 and CCL3) and humoral Th2 (IL‐4) immune responses. Serum antibodies to EBV virus capsid antigen (VCA) IgM and IgG antibodies were detected, together with a raised EBV DNA level (up to about 70,000 DNA copies/mL) in the acute phase of the illness. This EBV DNA load decreased rapidly in response to treatment with a combination of foscarnet, intravenous immunoglobulin and prednisolone, and the boy's symptoms settled eventually after approximately 50 days of illness, following this combined antiviral and immune‐modulating therapy. Detailed immunological, virological, haematological and biochemical laboratory parameters are presented to document this patient's severe EBV disease and eventual recovery. J. Med. Virol. 81:99–105, 2009. © 2008 Wiley‐Liss, Inc.