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Quantification of BK polyoma viruria in Japanese children and adults with hemorrhagic cystitis complicating stem cell transplantation
Author(s) -
Tanaka Kaori,
Hori Tsukasa,
Hatakeyama Naoki,
Yamamoto Masaki,
Takayama Rumiko,
Yoto Yuko,
Suzuki Nobuhiro,
Hayashi Toshiaki,
Ikeda Yukiho,
Ikeda Hiroshi,
Ishida Tadao,
Tsutsumi Hiroyuki
Publication year - 2008
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21328
Subject(s) - hemorrhagic cystitis , bk virus , urinary system , transplantation , medicine , viral load , risk factor , immunology , urine , urology , gastroenterology , virus , kidney transplantation , hematopoietic stem cell transplantation
Polyoma BK virus (BKV) is frequently found in the urine of stem cell transplantation (SCT) patients with hemorrhagic cystitis (HC), but also occurs in SCT patients without HC. How BK viruria relates to the development of HC in SCT patients, especially in children, has not yet been fully evaluated. In the present study, we analyzed the relationship of several factors including urinary BKV load to HC development in children and adults undergoing SCT. We employed a quantitative PCR assay and evaluated 37 patients (aged 9 months–62 years) of whom 12 developed HC and 25 did not. Older age was a risk factor for the development of HC; however, other factors such as sex, primary disease, type of SCT, conditioning regimen and aGVHD were not. Peak urinary BKV values in HC patients were not higher than those in non‐HC patients. Severity of HC also did not correlate with urinary BKV loads. However, in some patients who secreted higher urinary BKV loads, the peak loads were closely related with the onset of HC. Higher BKV loads may be a risk factor for the development of HC in conjunction with other coexisting factors. J. Med. Virol. 80:2108–2112, 2008. © 2008 Wiley‐Liss, Inc.