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High prevalence of hepatitis B virus infection in patients with B‐cell non‐Hodgkin's lymphoma in Korea
Author(s) -
Park Su Cheol,
Jeong SookHyang,
Kim Jin,
Han Chul Ju,
Kim You Cheoul,
Choi Kui Sung,
Cho Jang Hyun,
Lee Myoungjin,
Jung Ha Hyun,
Ki Seung Seog,
Chang Yoon Hwan,
Lee Seung Sook,
Park Yeon Hee,
Lee Kee Ho
Publication year - 2008
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21168
Subject(s) - lymphoma , hepatitis b virus , medicine , non hodgkin's lymphoma , virology , virus , hepatitis b , immunology
This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non‐Hodgkin's lymphoma in a highly HBV‐endemic area. The prevalence of either HBV or HCV infection in 235 patients with non‐Hodgkin's lymphoma was compared with that of an age‐ and sex‐matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B‐cell non‐Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non‐Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B‐cell non‐Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV‐infected non‐Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV‐infected non‐Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B‐cell non‐Hodgkin's lymphoma in Korea, suggesting a possible role for HBV in the development of non‐Hodgkin's lymphoma. J. Med. Virol. 80:960–966, 2008. © 2008 Wiley‐Liss, Inc.