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Epstein‐Barr virus immune response in high‐risk nasopharyngeal carcinoma families in Greenland
Author(s) -
Friborg Jeppe,
Jarrett Ruth F.,
Liu MeiYing,
Falk Kerstin I.,
Koch Anders,
Olsen Ove R.,
Duncan Pamela,
Wohlfarht Jan,
Chen JenYang,
Melbye Mads
Publication year - 2007
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21014
Subject(s) - nasopharyngeal carcinoma , serology , epstein–barr virus , virus , immunology , antibody , viral load , virology , carcinoma , peripheral blood mononuclear cell , epstein–barr virus infection , medicine , biology , pathology , genetics , in vitro , radiation therapy
Undifferentiated nasopharyngeal carcinoma is associated with Epstein‐Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high‐incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma‐high‐incidence area, we compared EBV serology and viral load in high‐risk nasopharyngeal carcinoma family members (N = 20) and controls without nasopharyngeal carcinoma‐affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti‐VCA IgA‐negative, anti‐VCA IgA‐positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) ( P < 0.01). The very high prevalence of anti‐VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits. J. Med. Virol. 79:1877–1881, 2007. © 2007 Wiley‐Liss, Inc.