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Post‐exposure prophylaxis with a maraviroc‐containing regimen after occupational exposure to a multi‐resistant HIV‐infected source person
Author(s) -
Méchai Frédéric,
Quertainmont Yann,
Sahali Sabrinel,
Delfraissy JeanFrançois,
Ghosn Jade
Publication year - 2008
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.21000
Subject(s) - maraviroc , medicine , regimen , post exposure prophylaxis , pre exposure prophylaxis , drug , human immunodeficiency virus (hiv) , virology , pharmacology , men who have sex with men , syphilis
We report the case of a health care worker who received a post‐exposure prophylaxis including an investigational drug, maraviroc, after a needle stick percutaneous injury to an HIV‐infected patient with late‐stage disease and harboring a multi‐drug resistant virus. Post‐exposure prophylaxis including maraviroc was pursued for a total of 28 days, with a weekly clinical and biological evaluation. Post‐exposure prophylaxis was well tolerated, with no increase in liver function tests. The health care worker remained HIV‐negative after a 6‐month follow‐up. J. Med. Virol. 80:9–10, 2008. © 2007 Wiley‐Liss, Inc.