Post‐exposure prophylaxis with a maraviroc‐containing regimen after occupational exposure to a multi‐resistant HIV‐infected source person

We report the case of a health care worker who received a post‐exposure prophylaxis including an investigational drug, maraviroc, after a needle stick percutaneous injury to an HIV‐infected patient with late‐stage disease and harboring a multi‐drug resistant virus. Post‐exposure prophylaxis including maraviroc was pursued for a total of 28 days, with a weekly clinical and biological evaluation. Post‐exposure prophylaxis was well tolerated, with no increase in liver function tests. The health care worker remained HIV‐negative after a 6‐month follow‐up. J. Med. Virol. 80:9–10, 2008. © 2007 Wiley‐Liss, Inc.