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Transplacental infection of coxsackievirus B3 pathological findings in the fetus
Author(s) -
Konstantinidou Anastasia,
Anninos Hector,
Spanakis Nikolaos,
Kotsiakis Xenophon,
Syridou Garyfallia,
Tsakris Athanassios,
Patsouris Efstratios
Publication year - 2007
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20887
Subject(s) - transplacental , myocarditis , medicine , coxsackievirus , fetus , autopsy , pathology , meningoencephalitis , arthrogryposis , asymptomatic , subclinical infection , pneumonitis , sepsis , pregnancy , lung , placenta , enterovirus , immunology , biology , virus , surgery , genetics
Abstract Coxsackievirus intrauterine infection has been documented mostly on the basis of indirect evidence of transplacental transmission, with neonatal manifestations ranging from asymptomatic infection to meningoencephalitis, myocarditis, and generalized sepsis. This is the first report of prenatal findings and fetoplacental pathology in a third trimester fetus with coxsackie B3 transplacental infection confirmed by molecular techniques. Prenatal ultrasound detected severe reduction of fetal movements at the 27th week. Late onset fetal akinesia deformation sequence with mild arthrogryposis, necrotic meningoencephalitis with vascular calcifications, interstitial pneumonitis, mild myocardial hypertrophy, and chronic monocytic placental villitis were the cardinal findings at fetal autopsy following interruption of the pregnancy. J. Med. Virol. 79: 754–757, 2007. © 2007 Wiley‐Liss, Inc.