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Relationship between mutations in HIV‐1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naïve and pre‐treated HIV infected patients
Author(s) -
Roquebert Bénédicte,
Wirden Marc,
Simon Anne,
Deval Jérome,
Katlama Christine,
Calvez Vincent,
Marcelin AnneGeneviève
Publication year - 2007
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20788
Subject(s) - rnase h , reverse transcriptase , nucleoside reverse transcriptase inhibitor , virology , mutation , nucleoside , rnase p , nucleoside analogue , biology , ribonuclease , microbiology and biotechnology , genetics , rna , gene
Recent studies have highlighted the need of investigating the in vivo role of ribonuclease H (RNase H) in nucleoside reverse transcriptase inhibitors (NRTIs) resistance. The prevalence of RNase H mutations in naive and in NRTI pre‐treated patients in regimen failure were compared and some specific associations between NRTI resistance mutations and RNase H mutations were determined. Four positions were mutated more frequently in pre‐treated patients than in naive patients: L469T/I/M/H, T470P/S/E/K, A554T/L/K, and K558R/G/E. Mutations at position K558 were also associated with the number of thymidine analog mutations (TAMs). These results suggest that these mutations could play a role in NRTI resistance. J. Med. Virol. 79:207–211, 2007. © 2007 Wiley‐Liss, Inc.