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Human herpesvirus 6 downregulates major histocompatibility complex class I in dendritic cells
Author(s) -
Hirata Yuko,
Kondo Kazuhiro,
Yamanishi Koichi
Publication year - 2001
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.2075
Subject(s) - major histocompatibility complex , mhc class i , downregulation and upregulation , biology , mhc class ii , virology , mhc restriction , immunology , antigen processing , immune system , cd74 , antigen presentation , gene , t cell , genetics
The expression of major histocompatibility complex (MHC) class I, class II, CD1a, and CD 83 in dendritic cells (DCs) after infection with human herpesvirus 6 (HHV‐6) was examined. Whereas there was no significant change in the expression of CD1a, CD83, and MHC class II in infected DCs, MHC class I expression was downregulated after infection with HHV‐6 variant A but not HHV‐6B. The expression of HHV‐6 immediate‐early or early genes was required for the downregulation of MHC class I. The de novo synthesis of MHC class I was greatly suppressed by infection with HHV‐6A in DCs, while its rate of degradation was only slightly elevated. These results suggest that HHV‐6A may escape from the host immune system in DCs by causing the downregulation of MHC class I synthesis. J. Med. Virol. 65:576–583, 2001. © 2001 Wiley‐Liss, Inc.