Premium
HIV replication elicits little cytopathic effects in vivo: Analysis of surrogate markers for virus production, cytotoxic T cell response and infected cell death
Author(s) -
Funk Georg A.,
Oxenius Annette,
Fischer Marek,
Opravil Milos,
Joos Beda,
Flepp Markus,
Weber Rainer,
Günthard Huldrych F.,
Bonhoeffer Sebastian
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20674
Subject(s) - cytopathic effect , virology , ctl* , biology , viral replication , virus , programmed cell death , cytotoxic t cell , in vivo , permissiveness , ex vivo , immunology , in vitro , apoptosis , genetics
Abstract Several potential mechanisms for viral destruction of HIV‐infected cells have been described. The hypothesis was examined that if HIV were cytopathic, a positive relation between the in vivo virus production or CTL activity and infected cell death should be observed. In a regression analysis no significant relation was found between surrogate markers for in vivo virus production or the virus‐specific CTL response and death rates of productively infected cells. In a subgroup of patients the hypothesis is rejected that HIV replication elicits a large (R 2 > 0.25) cytopathic effect ( P < 0.05, N = 36). It is concluded that HIV replication elicits little cytopathic effect in productively infected cells and that CD4 + T lymphocytes are eroded by other mechanisms. J. Med. Virol. 78:1141–1146, 2006. © 2006 Wiley‐Liss, Inc.