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CMV DNA detection in dried blood spots for diagnosing congenital CMV infection in Japan
Author(s) -
Yamagishi Yoshiaki,
Miyagawa Hiromi,
Wada Kazuko,
Matsumoto Sayuri,
Arahori Hitomi,
Tamura Arihiro,
Taniguchi Hidetoshi,
Kanekiyo Takahisa,
Sashihara Junji,
Yoda Tomoko,
Kitagawa Mikiya,
Ozono Keiichi
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20642
Subject(s) - dried blood , virology , spots , medicine , biology , pathology , chemistry , chromatography
Human cytomegalovirus (CMV) is a leading congenital infectious agent in developed countries. In the past, the incidence of congenital infection has been rather low in Japan because a high seroprevalence of CMV present in young women. However, this seroprevalence has been decreasing in recent years, so that the incidence of congenital CMV infection in Japanese neonates may increase and approach the level seen in other developed countries. The method was used for detecting CMV DNA reported by Barbi et al. [Barbi et al. (1996): Clin Diagn Virol 6:27–32] using a dried blood spot on filter paper, to diagnose congenital CMV infection in Japanese neonates. This method is effective and less laborious than virus isolation both for epidemiological studies and for identifying asymptomatic infected babies. Japanese neonates (1,176) were examined; two of who were asymptomatic were found to be infected. J. Med. Virol. 78:923–925, 2006. © 2006 Wiley‐Liss, Inc.