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High‐risk human papillomavirus infection of the genital tract of women with a previous history or current high‐grade vulvar intraepithelial neoplasia
Author(s) -
Goffin Frederic,
Mayrand MarieHélène,
Gauthier Philippe,
Alobaid A.,
Lussier Christian,
Provencher Diane,
Drouin Pierre,
Franco Eduardo L.,
Coutlée François
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20628
Subject(s) - vulvar intraepithelial neoplasia , hpv infection , medicine , vulvar carcinoma , odds ratio , vulva , cervical intraepithelial neoplasia , vulvar neoplasm , intraepithelial neoplasia , gynecology , papillomaviridae , human papillomavirus , sex organ , dermatology , cervical cancer , biology , cancer , genetics , prostate
Human papillomavirus (HPV) infection is associated with high‐grade vulvar intraepithelial neoplasia (VIN‐3). The prevalence of anogenital HPV infection in women with previously treated VIN‐3 has not been documented yet. This cross‐sectional study compared high‐risk HPV DNA detection rates in women with past (n = 30) and current (n = 22) VIN‐3 to those without current or past VIN (n = 86). HPV DNA was detected in vulvar and cervical samples with Hybrid Capture 2 (HC‐2). Smoking was associated in multivariate analysis with current VIN‐3 (odds ratio (OR) 8.3, 95% confidence interval (CI) 2.0–8.2) and any VIN‐3 history (OR 6.5, 95% CI 2.5–16.5). High‐risk HPV DNA was found on the vulva of 64%, 33%, and 20% of women with current VIN‐3, past VIN‐3, and without previous or current VIN, respectively. After controlling for age and smoking, high‐risk HPV vulvar infection was associated with cervical high‐risk HPV infection (OR 8.6, 95% CI 2.8–26.5; P = 0.001). After controlling for age, HPV infection was more often multifocal in women with current VIN‐3 compared to women with previous but no current VIN‐3 lesion (OR 17.6, 95% CI 1.4–227.2). Multifocal vulvar HPV infection was detected in women with previous or active VIN‐3. Longitudinal studies are required to determine if the multifocality of HPV infection on the vulva could explain the high recurrence rate of VIN‐3. J. Med. Virol. 78:814–819, 2006. © 2006 Wiley‐Liss, Inc.